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Wang et al. has viewed 842 articles in the field of primary and secondary prevention views.The conclusion was that an increased consumption of the omega-3 fatty acids EPA and DHA, through fish and/or through nutritional supplements, decreased both the overall mortality and the occurrence of heart attacks but also sudden cardiac death. Furthermore, it was of importance, that no or only very few complications occurred. A study from the Mayo Clinic confirms the protective effect of omega-3 fatty acid on the heart.

The nervous system has the highest fat percentage of all tissues in the body. According to Dr. David Horrobin, a pioneer in the research on essential fatty acids, approximately 8% of the brains exist of omega-3 fatty acids. In particular DHA is incorporated into phospholipid membranes and in de myelin sheath surrounding the nerve cells. For this reason omega-3 fatty acids are used for various mental disorders.

Some scientists claim that it is more likely that children who have deficiencies of Omega-3 fatty acids in their early years, later get ADHD or rather adopt an aggressive attitude. Studies into the effect of omega-3 fatty acids on ADHD partly show conflicting effects. Sometimes with positive effects on the results while in other studies no beneficial effects are found. The quality of some studies is not always that good.

Not only mice, but also people seem to be sensitive for the intake of Omega-3 fatty acids in relation to aggression. It turns out that murder is more common among people who use little omega-3 fatty acids. Low blood levels of these fatty acids are often seen in people who are fined for public violence. However through years of ingestion of omega-3 fatty acids, aggression decreases. A number of studies have found a positive effect of omega -3 fatty acids on impulse control /aggression shown.

A study by Andrew L. Stoll and colleagues of the Harvard-university is one of the first systematic attempts to clinically demonstrate the link between omega-3 fatty acids and improvement of the momentum transfer in the brains. They found that patients with bipolar disorder (also called manic depressive illness) had significantly improved compared to the placebo group after using fish oil supplementation for nine months.

Currently much research is going into the influence of 0mega-3 fatty acids on the momentum transfer in nerve tissue and its clinical effect. Meanwhile it has been shown that omega-3 fatty acids provide a positive contribution to the treatment of bipolar disorder.

The omega-3 fatty acid committee of the American Psychiatric Association (APA) has analyzed the studies on the potential beneficial effects of omega-3 fatty acids and concludes that they have a beneficial effect on depression.

Animals tests show that brain function and blood flow are favorably affected by the use of Omega-3 fatty acids. Theoretically omega-3 fatty acids would reduce the risk of developing Alzheimer’s disease. However, this is not evident from research: sometimes the results of studies are contradictory or the quality of the studies is insufficient.

Epidemical studies show a link between a low intake of omega-3- fatty acids and the occurrence of psychosis .In clinical studies omega-3 fatty acids appear to have a beneficial effect on the treatment of schizophrenia and the prevention of this disease. With youngsters it appears to work equally well as the currently available neuroleptics (atypical antipsychotics)

Because of the anti-inflammatory properties of omega-3 fatty acids, these fatty acids have also been studied in the context of inflammatory diseases and auto-immune diseases (such as Crohn’s disease and rheumatoid arthritis).The beneficial effects of omega- 3 fatty acids in rheumatoid arthritis have been demonstrated. Anti-inflammatory effects were observed in fish oil doses between 2.6 - 7.1 grams of Omega- 3 fatty acids ( EPA + DHA) per day .

omega-3 fatty acids can contribute to the prevention of macular degeneration (MD). However, the studies accompanied by such contradict each other and are not of equally good quality in all cases. Therefore, one cannot make recommendations concerning the use of omega-3 fatty acids for the prevention of MD .The eyesight of infants improve by supplementation with omega-3 fatty acids. Because of the role of omega-3 fatty acids in the development of the immune and vascular system of the newborns no use advice can be given for safety reasons. Larger studies are needed to better map the safety and effectiveness .